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Rabbit Anti-FAT/APC Conjugated antibody (bs-4278R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4278R-APC
英文名稱 Rabbit Anti-FAT/APC Conjugated antibody
中文名稱 APC標記的鈣粘蛋白家族成員7抗體
別    名 Cadherin family member 7; cadherin family member 7 precursor; cadherin ME5; Cadherin related tumor suppressor; Cadherin related tumor suppressor homolog; cadherin related tumor suppressor homolog precursor; Cadherin related tumor suppressor homolog precursor (FAT protein homolog); CDHF 7; CDHF7; FAT 1; FAT tumor suppressor 1; FAT tumor suppressor homolog 1; FAT1; hFat 1; hFAT; hFat1; homolog of Drosophila FAT protein; homolog of Drosophila FAT protein precursor; homolog of Drosophila tumor suppressor FAT precursor; ME 5; ME5; Protein fat homolog.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  細胞周期蛋白  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 506kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FAT/CDHF7
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq].

Function:
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.

Subunit:
Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH. Interacts (via cytoplasmic domain) with CTNNB1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Nucleus Cytoplasm, perinuclear region.

Tissue Specificity:
Expressed in many epithelial and some endothelial and smooth muscle cells.

Post-translational modifications:
Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.

Database links:


Entrez Gene: 2195 Human

Entrez Gene: 14107 Mouse

Omim: 600976 Human

SwissProt: Q14517 Human

Unigene: 481371 Human

Unigene: 27365 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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