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Rabbit Anti-Syndecan 4/RBITC Conjugated antibody (bs-2926R-RBITC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2926R-RBITC
英文名稱1 Rabbit Anti-Syndecan 4/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的多配體聚糖4抗體
別    名 Amphiglycan; Amphiglycan; MGC22217; OTTHUMP00000031788; ryudocan amphiglycan; Ryudocan; Ryudocan core protein; Ryudocan core protein; SDC 4; SDC4; SDC4_HUMAN; SYND 4; SYND4; syndecan 4; syndecan 4 (amphiglycan, ryudocan); syndecan proteoglycan 4; Syndecan-4; Syndecan4.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Cow,  (predicted: Human, Mouse, Rat, Dog, Pig, )
產(chǎn)品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Syndecan 4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Syndecans are type I integral membrane proteoglycans that are involved in cell-extracellular matrix adhesion and growth factor binding. Syndecan 1 is a matrix receptor which binds to Collagens, Fibronectin and Thrombospondin. Syndecan 1 and Syndecan 3 interact with MK (midkine), a growth/differentiation factor involved in embryogenesis. Syndecan 2 is highly expressed at areas of high morphogenetic activity, such as epithelial-mesenchymal interfaces and the prechondrogenic and preosteogenic mesenchymal condensations. Syndecan 4 functions cooperatively with integrins in the processes of cell spreading and focal adhesion assembly. Syndecan-4 is a transmembrane protein specifically enriched in Schwann cell perinodal processes.

Function:
Cell surface proteoglycan that bears heparan sulfate.

Subunit:
Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1. Interacts with CDCP1 and SDCBP.

Subcellular Location:
Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
Isoform 2: Secreted.

Tissue Specificity:
Expressed in epithelial and fibroblastic cells.

Post-translational modifications:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Similarity:
Belongs to the syndecan proteoglycan family.

Database links:

Entrez Gene: 6385 Human

Entrez Gene: 20971 Mouse

Entrez Gene: 24771 Rat

Omim: 600017 Human

SwissProt: P31431 Human

SwissProt: O35988 Mouse

SwissProt: P34901 Rat

Unigene: 632267 Human

Unigene: 3815 Mouse

Unigene: 2029 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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