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Rabbit Anti-Dexras1/PE-Cy5.5 Conjugated antibody (bs-14284R-PE-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-14284R-PE-Cy5.5
英文名稱 Rabbit Anti-Dexras1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的G蛋白信號傳導(dǎo)激活蛋白1抗體
別    名 Activator of G protein signaling 1; Activator of G protein signaling; Activator of G-protein signaling 1; AGS 1; AGS1; Dexamethasone induced ras related protein 1; Dexamethasone-induced ras protein 1; Dexamethasone-induced Ras-related protein 1; Dexras 1; MGC:26290; RAS dexamethasone induced 1; Ras protein, Dexamethasone-induced, 1; Ras related protein; RASD 1; Rasd1; RASD1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 信號轉(zhuǎn)導(dǎo)  細(xì)胞分化  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dexras1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

Function:
Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65.

Subcellular Location:
Cell membrane. Cytoplasm > perinuclear region. Nucleus.

Tissue Specificity:
Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.

Post-translational modifications:
S-nitrosylation stimulates guanine-nucleotide exchange activity.

Similarity:
Belongs to the small GTPase superfamily. RasD family.

Database links:

Entrez Gene: 51655 Human

Entrez Gene: 19416 Mouse

Omim: 605550 Human

SwissProt: Q9Y272 Human

SwissProt: O35626 Mouse

Unigene: 25829 Human

Unigene: 3903 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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