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Rabbit Anti-DGKZ/Gold Conjugated antibody (bs-14301R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-14301R-Gold
英文名稱 Rabbit Anti-DGKZ/Gold Conjugated antibody
中文名稱 膠體金標記的甘油二酯激酶ζ/DGK-ζ抗體
別    名 DAG kinase zeta; DAGK5; DAGK5 PEN; DAGK6; DGK ZETA; DGK-zeta; Dgkz; DGKZ_HUMAN; Diacylglycerol kinase zeta; Diglyceride kinase zeta; hDGKzeta.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 心血管  細胞生物  信號轉導  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Pig, Cow, Guinea Pig, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 124kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DGKZ
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

Function:
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane.

Tissue Specificity:
Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Post-translational modifications:
Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.

Similarity:
Belongs to the eukaryotic diacylglycerol kinase family.
Contains 2 ANK repeats.
Contains 1 DAGKc domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.

Database links:

Entrez Gene: 8525 Human

Entrez Gene: 423197 Chicken

Entrez Gene: 483635 Dog

Entrez Gene: 100050499 Horse

Entrez Gene: 104418 Mouse

Entrez Gene: 81821 Rat

Omim: 601441 Human

SwissProt: Q13574 Human

SwissProt: Q80UP3 Mouse

SwissProt: O08560 Rat

Unigene: 502461 Human

Unigene: 314923 Mouse

Unigene: 11208 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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