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Rabbit Anti-MGST1/PE-Cy5 Conjugated antibody (bs-12206R-PE-Cy5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-12206R-PE-Cy5
英文名稱 Rabbit Anti-MGST1/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的微粒體谷胱甘肽S轉(zhuǎn)移酶1抗體
別    名 MGST1; Glutathione S transferase 12; Microsomal glutathione transferase 1; GST12; MGST 1; MGST; MGST1; MGST1_HUMAN; Microsomal glutathione S-transferase 1; Microsomal GST 1; Microsomal GST-1; Microsomal GST-I.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MGST1 (101-155aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Subcellular Location:
Microsome. Mitochondrion outer membrane. Endoplasmic reticulum membrane.

Tissue Specificity:
Highly expressed in liver.

Post-translational modifications:
Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.

Similarity:
Belongs to the MAPEG family.

Database links:

Entrez Gene: 4257 Human

Entrez Gene: 56615 Mouse

Entrez Gene: 171341 Rat

Omim: 138330 Human

SwissProt: P10620 Human

SwissProt: Q91VS7 Mouse

SwissProt: P08011 Rat

Unigene: 389700 Human

Unigene: 14796 Mouse

Unigene: 2580 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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