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Rabbit Anti-TMEM16C/Gold Conjugated antibody (bs-12479R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-12479R-Gold
英文名稱 Rabbit Anti-TMEM16C/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的跨膜蛋白16C抗體
別    名 Anoctamin 3; ANO3; C11orf25; GENX 3947; TMEM16C; Transmembrane protein 16C (eight membrane spanning domains); Transmembrane protein 16C; ANO3_HUMAN; DYT23; DYT24; GENX-3947.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  新陳代謝  跨膜蛋白  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 115kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEM16C/Anoctamin 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
TMEM16C is a 981 amino acid multi-pass membrane protein that is encoded by a gene which maps to chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.

Function:
Anoctamin 3 belongs to the anoctamin family. Anoctamin 3 may act as a calcium activated chloride channel.

Subcellular Location:
Membrane; Multi pass membrane protein.

Similarity:
Belongs to the anoctamin family.

Database links:

Entrez Gene: 63982 Human

Entrez Gene: 228432 Mouse

Entrez Gene: 100519534 Pig

Entrez Gene: 311287 Rat

Omim: 610110 Human

SwissProt: Q9BYT9 Human

SwissProt: A2AHL1 Mouse

SwissProt: F1SFZ6 Pig



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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