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Rabbit Anti-KREMEN2/PE-Cy5 Conjugated antibody (bs-16813R-PE-Cy5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-16813R-PE-Cy5
英文名稱 Rabbit Anti-KREMEN2/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的跨膜蛋白KREMEN2抗體
別    名 Dickkopf receptor 2; KREM2_HUMAN; KREMEN 2; Kremen protein 2; Kremen protein 2 precursor; Kremen2; Kringle containing protein marking the eye and the nose; Kringle containing transmembrane protein 2; Kringle domain containing transmembrane protein 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; KRM 2; KRM2; MGC10791; MGC16709.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞類型標(biāo)志物  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KREMEN2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function:
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane.

Subcellular Location:
Membrane.

Similarity:
Contains 1 CUB domain.
Contains 1 kringle domain.
Contains 1 WSC domain.

Database links:

Entrez Gene: 79412 Human

Entrez Gene: 73016 Mouse

Entrez Gene: 287102 Rat

Omim: 609899 Human

SwissProt: Q8NCW0 Human

SwissProt: Q8K1S7 Mouse

Unigene: 661128 Human

Unigene: 221319 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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