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Rabbit Anti-KAT2A/GCN5/Cy7 Conjugated antibody (bs-17076R-Cy7)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-17076R-Cy7
英文名稱(chēng) Rabbit Anti-KAT2A/GCN5/Cy7 Conjugated antibody
中文名稱(chēng) Cy7標(biāo)記的組蛋白乙?;D(zhuǎn)移酶GCN5抗體
別    名 1110051E14Rik; AW212720; EC 2.3.1.48; GCN 5; GCN5 (general control of amino acid synthesis yeast homolog) like 2; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; Gcn5; GCN5 general control of amino acid synthesis 5 like 2; GCN5 general control of amino-acid synthesis 5-like 2 (yeast); GCN5 like 2; GCN5L2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5 like 2; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis yeast homolog like 2; General control of amino acid synthesis, yeast, homolog-like 2; HGCN 5; HGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KAT2 A; KAT2A; KAT2A_HUMAN; Lysine acetyltransferase 2A; MGC102791; PCAF-b; STAF97.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KAT2A/GCN5
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

Function:
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in all tissues tested, with most abundant expression in ovary.

Similarity:
Belongs to the GCN5 family.
Contains 1 bromo domain.
Contains 1 N-acetyltransferase domain.

Database links:

Entrez Gene: 2648 Human

Entrez Gene: 14534 Mouse

Omim: 602301 Human

SwissProt: Q92830 Human

SwissProt: Q9JHD2 Mouse

Unigene: 463045 Human

Unigene: 218837 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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