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Rabbit Anti-MPZL/APC Conjugated antibody (bs-17744R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-17744R-APC
英文名稱 Rabbit Anti-MPZL/APC Conjugated antibody
中文名稱 APC標記的髓鞘蛋白P0樣蛋白1抗體
別    名 immunoglobulin family transmembrane protein; MPZL1; MPZL1b; MPZL1_HUMAN; myelin protein zero like 1; myelin protein zero like protein 1 precursor; myelin protein zero like protein MPZL1b; OTTHUMP00000032519; protein zero related; PZR; PZR1b; PZRa; PZRb.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  神經生物學  信號轉導  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MPZL
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MPZL1 is a 269 amino acid widely expressed single-pass type I membrane receptor belonging to the myelin P0 protein family and the immunoglobulin superfamily. MPZL2 (myelin protein zero-like 2), also known as EVA (epithelial V-like antigen) or EVA1, is a 215 amino acid single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain and two potential N-glycosylation sites in its extracellular domain, MPZL2 is expressed in thymus epithelium and is strongly down-regulated by thymocyte developmental progression. MPZL3 (myelin protein zero-like 3) is a 235 amino acid single-pass type I membrane protein that regulates homophilic cell-to-cell adhesion. A member of the myelin P0 protein family, MPZL3 contains one Ig-like V-type (immunoglobulin-like) domain and is expressed in brain, heart, liver and skin. g to the myelin P0 protein family and the immunoglobulin superfamily. Existing as four alternatively spliced isoforms, MPZL1 participates in signal transduction and cell migration.

Function:
Cell surface receptor, which is involved in signal transduction processes. Is a major receptor for concanavalin A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine protein kinases. Isoform 3 seems to block tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, unlike isoforms 2 and 3, may be involved in regulation of integrin mediated cell motility.

Subunit:
Interacts with phosphorylated PTPN11/SHP-2.

Subcellular Location:
Membrane; single pass type I membrane protein (Potential)

Tissue Specificity:
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.

Post-translational modifications:
Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).
N-glycosylated.

Similarity:
Belongs to the myelin P0 protein family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 9019 Human

Omim: 604376 Human

SwissProt: O95297 Human

Unigene: 493919 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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