| 產(chǎn)品編號 | bs-18366R-BF488 |
| 英文名稱 | Rabbit Anti-LRP5 + LRP6/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的低密度脂蛋白受體相關(guān)蛋白5+6抗體 |
| 別 名 | BMND 1; BMND1; EVR 1; EVR 4; EVR1; EVR4; FLJ90062; FLJ90421; HBM; LDL Receptor Related Protein 5 + 6; Low density lipoprotein receptor related protein 5; Low density lipoprotein receptor related protein 5 precursor; Low density lipoprotein receptor related protein 6; Low density lipoprotein receptor related protein 6 precursor; LR 3; LR3; LRP 5; LRP 6; LRP 7; LRP7; OPPG; OPS; OPTA 1; OPTA1; VBCH 2; VBCH2. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 細(xì)胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 176kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRP5 + LRP6 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization. Subcellular Location: Membrane; single-pass type I membrane protein Similarity: Belongs to the LDLR family. Contains 4 EGF-like domains. Contains 3 LDL-receptor class A domains. Contains 20 LDL-receptor class B repeats. Database links: Entrez Gene: 4040 Human Entrez Gene: 4041 Human Entrez Gene: 16973 Mouse Entrez Gene: 16974 Mouse Omim: 603506 Human Omim: 603507 Human SwissProt: O75197 Human SwissProt: O75581 Human SwissProt: O88572 Mouse SwissProt: Q91VN0 Mouse Unigene: 45360 Human Unigene: 584775 Human Unigene: 6347 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
