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Rabbit Anti-LRP5 + LRP6/BF555 Conjugated antibody (bs-18366R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-18366R-BF555
英文名稱 Rabbit Anti-LRP5 + LRP6/BF555 Conjugated antibody
中文名稱 BF555標記的低密度脂蛋白受體相關蛋白5+6抗體
別    名 BMND 1; BMND1; EVR 1; EVR 4; EVR1; EVR4; FLJ90062; FLJ90421; HBM; LDL Receptor Related Protein 5 + 6; Low density lipoprotein receptor related protein 5; Low density lipoprotein receptor related protein 5 precursor; Low density lipoprotein receptor related protein 6; Low density lipoprotein receptor related protein 6 precursor; LR 3; LR3; LRP 5; LRP 6; LRP 7; LRP7; OPPG; OPS; OPTA 1; OPTA1; VBCH 2; VBCH2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  細胞膜受體  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 176kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LRP5 + LRP6
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

Subcellular Location:
Membrane; single-pass type I membrane protein

Similarity:
Belongs to the LDLR family.
Contains 4 EGF-like domains.
Contains 3 LDL-receptor class A domains.
Contains 20 LDL-receptor class B repeats.

Database links:

Entrez Gene: 4040 Human

Entrez Gene: 4041 Human

Entrez Gene: 16973 Mouse

Entrez Gene: 16974 Mouse

Omim: 603506 Human

Omim: 603507 Human

SwissProt: O75197 Human

SwissProt: O75581 Human

SwissProt: O88572 Mouse

SwissProt: Q91VN0 Mouse

Unigene: 45360 Human

Unigene: 584775 Human

Unigene: 6347 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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