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Rabbit Anti-GRP/APC Conjugated antibody (bs-14364R-APC)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-14364R-APC
英文名稱 Rabbit Anti-GRP/APC Conjugated antibody
中文名稱 APC標(biāo)記的促胃泌素釋放肽抗體
別    名 Gastrin releasing peptide; BN; Bombesin; GRP 10; GRP10; Neuromedin C; NeuromedinC; Pre progastrin releasing peptide; preproGRP; proGRP; GRP_HUMAN. Gastrin releasing peptide precursor.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  新陳代謝  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 3kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Gastrin Releasing Peptide
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Function:
GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus.

Similarity:
ngs to the bombesin/neuromedin-B/ranatensin family.

Database links:

Entrez Gene: 2922 Human

Entrez Gene: 225642 Mouse

Entrez Gene: 171101 Rat

Omim: 137260 Human

SwissProt: P07492 Human

SwissProt: Q8R1I2 Mouse

SwissProt: P63153 Pig

SwissProt: P24393 Rat

Unigene: 153444 Human

Unigene: 20298 Mouse

Unigene: 10930 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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