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Rabbit Anti-NARFL/AP Conjugated antibody (bs-19019R-AP)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-19019R-AP
英文名稱 Rabbit Anti-NARFL/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的NARFL蛋白抗體
別    名 Cytosolic Fe-S cluster assembly factor NARFL; FLJ21988; HPRN; IOP1; Iron only hydrogenase like protein 1; iron-only hydrogenase-like protein 1; LET1 like/JFP15; LET1L; Nuclear prelamin A recognition factor like; Nuclear prelamin A recognition factor like protein; nuclear prelamin A recognition factor-like protein; PRN; Protein related to Narf; uclear prelamin A recognition factor-like.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Chicken, Dog, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NARFL
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
產(chǎn)品介紹 background:
NARFL (nuclear prelamin A recognition factor-like), also known as cytosolic Fe-S cluster assembly factor NARFL, HPRN, PRN (protein related to Narf), LET1L or IOP1 (iron-only hydrogenase-like protein 1), is a 476 amino acid protein belonging to the NARF family. Widely expressed, NARFL is required for extramitochondrial sulfur and iron protein maturation and may indirectly negatively regulate HIF-1?expression. Existing as three alternatively spliced isoforms, NARFL is encoded by a gene that maps to human chromosome 16p13.3 and murine chromosome 17 A3.3.

Function:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

Subcellular Location:
Nuclear Cytosolic iron-sulfur protein assembly complex.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the NARF family.

Database links:

Entrez Gene: 64428 Human

Omim: 611118 Human

SwissProt: Q9H6Q4 Human

Unigene: 513247 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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