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Rabbit Anti-Neurexin-3-beta/BF488 Conjugated antibody (bs-9117R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-9117R-BF488
英文名稱 Rabbit Anti-Neurexin-3-beta/BF488 Conjugated antibody
中文名稱 BF488標記的軸突蛋白3 beta抗體
別    名 Neurexin-3-beta; Neurexin III-beta; Neurexin-3-beta, soluble form; NRX3B_HUMAN; NRXN3; KIAA0743.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 神經(jīng)生物學  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Chicken, Cow, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neurexin-3-beta
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]

Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis.

Subunit:
The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).

Tissue Specificity:
Expressed in the blood vessel walls (at protein level).

Post-translational modifications:
Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides.

Similarity:
Belongs to the neurexin family.
Contains 1 laminin G-like domain.

Database links:

Entrez Gene: 9369 Human

Entrez Gene: 18191 Mouse

Entrez Gene: 116508 Rat

Omim: 600567 Human

SwissProt: Q9HDB5 Human

SwissProt: Q9Y4C0 Human

SwissProt: Q6P9K9 Mouse

SwissProt: Q8C985 Mouse

SwissProt: Q8CCT8 Mouse

SwissProt: Q07310 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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