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Rabbit Anti-Pannexin 1/BF594 Conjugated antibody (bs-21015R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-21015R-BF594
英文名稱 Rabbit Anti-Pannexin 1/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的間隙連接蛋白PANX1抗體
別    名 innexin; MRS1; Pannexin 1; Pannexin-1; Panx1; PANX1_HUMAN; PX1; UNQ2529.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pannexin 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Function:
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

Subunit:
Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).

Subcellular Location:
Cell membrane. Cell junction > gap junction. Endoplasmic reticulum membrane.

Similarity:
Belongs to the pannexin family.

Database links:

Entrez Gene: 24145 Human

Entrez Gene: 55991 Mouse

Entrez Gene: 100171730 Orangutan

Entrez Gene: 315435 Rat

Omim: 608420 Human

SwissProt: Q96RD7 Human

SwissProt: Q9JIP4 Mouse

SwissProt: Q5REE3 Orangutan

SwissProt: P60570 Rat

Unigene: 591976 Human

Unigene: 142253 Mouse

Unigene: 204521 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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