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Rabbit Anti-SLC7A5/Biotin Conjugated antibody (bs-23997R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-23997R-Bio
英文名稱 Rabbit Anti-SLC7A5/Biotin Conjugated antibody
中文名稱 生物素標記的CD98輕鏈抗體
別    名 LAT1; 4F2 LC; 4F2 light chain; SLC7A5; 4F2LC; CD98; CD98 light chain; CD98LC; D16S469E; DC49; E16; hLAT1; Integral membrane protein E16; L type amino acid transporter; L type amino acid transporter 1; L-type amino acid transporter 1; Large neutral amino acids transporter 1; Large neutral amino acids transporter; Large neutral amino acids transporter small subunit 1; LAT1_HUMAN; Membrane protein E16; MPE16; Slc7a5; Sodium independent neutral amino acid transporter; Sodium independent neutral amino acid transporter LAT1; Solute carrier family 7 (cationic amino acid transporter y+ system) member 5; Solute carrier family 7 member 5; TA1; Tumor associated protein 1; y+ system cationic amino acid transporter.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  新陳代謝  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Mouse, Rat, )
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse SLC7A5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
L-type amino acid transporter 1 (LAT1) is a multipass-membrane protein responsible for sodium-independent, high-affinity transport of large neutral amino acids. LAT1 functions as a disulfide-linked heterodimer with the amino acid transport protein CD98. LAT1 is expressed predominantly in adult lung and liver but is also expressed in brain, thymus, retina, testis, placenta, bone marrow and fetal liver. In the retina, LAT1 localizes to the blood-retinal-barrier (BRB) and mediates L-leucine transport from the blood to the retina. The devastating effects on the brain caused by phenylketonuria are due to the increased levels of LAT1 on the blood-brain-barrier in response to high concentrations of phenylalanine in the blood. LAT1 accepts the amino-acid related anticancer agent melphalan and plays a significant role in cell proliferation, differentiation, and invasion in esophageal squamous cell carcinoma.

Function:
L-type amino acid transporter 1 (LAT1) is a multipass-membrane protein responsible for sodium-independent, high-affinity transport of large neutral amino acids. LAT1 functions as a disulfide-linked heterodimer with the amino acid transport protein CD98. LAT1 is expressed predominantly in adult lung and liver but is also expressed in brain, thymus, retina, testis, placenta, bone marrow and fetal liver. In the retina, LAT1 localizes to the blood-retinal-barrier (BRB) and mediates L-leucine transport from the blood to the retina. The devastating effects on the brain caused by phenylketonuria are due to the increased levels of LAT1 on the blood-brain-barrier in response to high concentrations of phenylalanine in the blood. LAT1 accepts the amino-acid related anticancer agent melphalan and plays a significant role in cell proliferation, differentiation, and invasion in esophageal squamous cell carcinoma.

Subcellular Location:
Cytoplasm, cytosol. Apical cell membrane. Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells.

Tissue Specificity:
Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.

Similarity:
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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