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Rabbit Anti-BMP7/BF488 Conjugated antibody (bs-10506R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10506R-BF488
英文名稱 Rabbit Anti-BMP7/BF488 Conjugated antibody
中文名稱 BF488標記的骨形態(tài)發(fā)生蛋白7抗體
別    名 bone morphogenetic protein 7 precursor; osteogenic protein 1; BMP-7; OP-1; BMP 7; Bone morphogenic protein 7; Eptotermin alfa; OP 1; OP1; BMP7_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  細胞凋亡  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human BMP7
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq].

Function:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subunit:
Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in the kidney and bladder. Lower levels seen in the brain.

Post-translational modifications:
Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).

Similarity:
Belongs to the TGF-beta family.

Database links:

Entrez Gene: 477270 Dog

Entrez Gene: 655 Human

Entrez Gene: 12162 Mouse

Entrez Gene: 492315 Pig

Entrez Gene: 85272 Rat

Omim: 112267 Human

SwissProt: P18075 Human

SwissProt: P23359 Mouse

Unigene: 473163 Human

Unigene: 595 Mouse

Unigene: 18030 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

骨形態(tài)發(fā)生蛋白7(BMP-7)是轉(zhuǎn)化生長因子β超家族成員,參與器官發(fā)生,細胞增殖、分化及凋亡等.
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