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Rabbit Anti-Claudin 2/Gold Conjugated antibody (bs-23849R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-23849R-Gold
英文名稱 Rabbit Anti-Claudin 2/Gold Conjugated antibody
中文名稱 膠體金標記的緊密連接蛋白2抗體
別    名 Claudin-2; Claudin2; CLD2_HUMAN; CLDN 2; CLDN2; OTTHUMP00000023793; SP 82; SP82.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  免疫學  信號轉導  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Claudin 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin superfamily. Able to form homopolymers of heteropolymers with other claudin family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further affirming the importance of claudin-2 in cell adhesion. The gene encoding claudin-2 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Subunit:
Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).

Subcellular Location:
Cell junction; tight junction. Cell membrane.

Similarity:
Belongs to the claudin family.

Database links:
Entrez Gene: 404089 Cow

Entrez Gene: 9075 Human

Entrez Gene: 12738 Mouse

Entrez Gene: 300920 Rat

Omim: 300520 Human

SwissProt: P57739 Human

SwissProt: O88552 Mouse

Unigene: 522746 Human

Unigene: 117068 Mouse

Unigene: 93431 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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